It's possible that 12.10 is slower than 12.8 on this particular instance of you problem, or even on your problems in general. New releases are generally faster than their predecessors on the bulks of IBM's test suite, but given the perverse nature of integer programs, it's asking a bit much for a new version to be faster across the board.
It is possible that by adjusting some parameters off their default settings you might do better with 12.10. CPLEX has a tuning tool which can automatically try various parameter combinations and make suggestions. If you decide to try it, I would suggest running it on a fairly small (but not trivial) problem instance. If you want to post one of the instances to the forum, possibly someone would have time to play with it and see if the reason for the slowness can be identified. (If you do post it, I would recommend a .sav file rather than a .lp file, as the .sav file is a bit more accurate numerically.)
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Paul Rubin
Professor Emeritus
Michigan State University
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