Attached is a great demo of the IBM z MFA V2 solution done by Mike Zagorski, the IBM Offering Manager. It covers several of the factors available: 

• Yubikey
• RSA SecureID
• Smart Card
• IBM Cloud Identity Verify

The magic of the z MFA solution is that it can interoperate with many third party MFA offerings. As a result, a business can have a consistent sign on to all their critical system infrastructure.
And don't forget, just because MFA may be in use on a desktop or mobile device, those don't protect potential theft of userid and password for the mainframe. So make sure that all your key applications are using MFA as a more secure authentication method.