The most important difference for the DS8000 G10 system is the change in the RAID adapter and drives. So you need to consider which drive type to use here and in almost all situations you want to use a single type and size of drive. The main choice is whether you want to take advantage of FlashCore Modules and compression or to use Industry Standard drives.
If you are replacing an existing system then in general you should consider larger drives than the current system as the new NVMe drives provide higher performance per drive set. In general I would start with the same number of Host Adapters and equal or larger cache as the old system unless there is significant growth planned.
You might want to discuss the configuration and opportunity with your IBM Partner Technical Specialist to discuss the specifics.