Filters are applied on the HSTS and you can configure specific file extensions to never be uploaded or downloaded.
https://www.ibm.com/docs/en/ahts/4.4.x?topic=gui-configuring-filters-include-exclude-files
Faspex has a feature called File Processing, which can validate files that are uploaded and can allow or deny each file based on file names or file contents.
https://www.ibm.com/docs/en/aspera-faspex/5.0?topic=configuration-enabling-file-processing