Hi Irfan
Did you find a solution?
Additional question, you did not change the generated message flow, have you?
You mention the ACE logs, but you have no explicit logging in your screenshots. You mean the activity log then?
The fact that it works after restarting does seem to indicate en issue like a memory leak or open ipprocs or something else that builds over time.
The 3742 error indicates you send multiple replies, but that is not clear from your screenshots. Can you check the log timestamps, is 3742 coming from the reply your API gives or from a bit later, after the configured timeout.
How heavy is that flow taxed? You mention restarting the nodes, so I assume you are running ACE Nodes with multiple integration servers. Are you using node wide listener or embedded listener?
You also mention JDBC, but not used by this flow then?