I have build a cluster in WAS 8.5.5..
one manager profile + cluster profile in one machine
2 seperate nodes on seperate machines
all 3 in seperate boxes... if any application directly calling websphere application from outside which is my destination
 either DMGR or Node1 or Node 2.
I dont have webserver in cluster environment..
could you please some one answer this... 

Hi,
if you don't have in your architecture for example IHS, each node is destination for your application.

See my design

In my Scnario
one deployment Manager (Managment Profile) and 2 Nodes (Custom Profile) are in separate boxes.
Now i need to connect a application an from outside directly to WAS application server...
There is no IIS or HTTP server here.
How can i setup cluster in my scenario.
I can have only one destination IP address from outside of WAS cell. I cannot have multiple destinations
Please advise me how can we steup in this scenario.

Wouldn't you configure a load balanced address at your F5 level.  The F5 load balanced name would then redirect to both internal WebServers (jvm cluster).  

You can use the ODR(on demand router) to invoke an application which is deployed at a cluster level.Else you will have to use the port of the server on which the application is hosted on separately.In such a case you will loose the feature of HA provided by cluster.