I think your broker is not running:
2013-05-16 17:36:38 BST [ISS.0099.0003E] Unable to create Broker Transport 10.205.0.210_5555_LoggingUtility_AC. Exception com.wm.app.b2b.server.dispatcher.exceptions.EndpointUnavailableException: [ISS.0098.9014] BrokerException: Comm Failure (102-2050): Unable to open connection to host ‘localhost’. Error ‘java.net.ConnectException: Connection refused: connect’ was reported by the socket call.
2013-05-16 17:36:38 BST [LGU.0001.0003C] Error creating broker admin client:
2013-05-16 17:36:38 BST [ADA.7180.0004D] Custom Classpath entries are:
try to bring up the broker (search services list for broker)
#Integration-Server-and-ESB#webMethods-General#webMethods