In Enterprise Server we are currently connecting to DB2/AS400 using the JDBC adapter with the com.ibm.as400.access.AS400JDBCDriver driver.
I’ve also connected with my own custom JDBC adapter using the Hits Software driver for the AS400.
I would think that you could just create a database alias using either of these drivers. The IBM driver you can download for free.
#Integration-Server-and-ESB#webMethods#Adapters-and-E-Standards