If you’re going to wait, you should wait for 6.1 (or 6.5). The .0 release of any product has headaches and this one will probably have some growing pains given the breadth and depth of the changes being made.
I believe 6.5 will have upgrade/migration tools, though if you’re only using B2B Server/Integration Server this probably isn’t as important.
As far as information on feature updates/bug fixes you can look at the release notes for 4.6 in Advantage.
#Integration-Server-and-ESB#webMethods-Upgrade#webMethods-General#webMethods