Hi,
I do think it is possible, but you could use other softwares just for that (apache, nginx, etc).
If, however, you are thinking on using a Mediator as a reverse proxy, you will need to have the remaining platform also on 10.1 to manage it (CentraSite, API) whilst being able to connect to you old 8.0.
Best regards,
#Integration-Server-and-ESB#webMethods