There can be multiple reasons for this error.
I got Kerberos related error while connecting to JDBC adapters when i updated my DB password.
One reason could be CRM updated some configuration at their end because of which password got changed or something.
Basically you need to check with CRM team if they are able to access the WSDL and Execute it.
However, Cross check if you are passing valid credentials.
Regards,
Syed Faraz Ahmed
#webMethods#Integration-Server-and-ESB