I have never encountered any http header limits with Integration Server. And it make sense since HTTP headers are used in many ways that may approach the size of header way higher than usual. Eg. Kerberos tickets in HTTP headers can be usually as big as 8 kb Itself. On top of it you may include singnature or any other header details.
For conformaiton, please check with Software AG support.
#Integration-Server-and-ESB#webMethods-General#webMethods