I am assuming you are talking about SOAP web service exposed by webMethods since you mentioned WSDL and are posting in SAG wM Tech forums.
For SOAP, you can create a web or service reference using the WSDL URL in VS. This will generate the required proxy with all the operations in the WSDL a methods to call the web services from .NET app. You can access the methods in this proxy class as a regular .NET method in your method once you initialize the web reference in your code. There are numerous examples out there on how to consume a WSDL in .NET.
#Integration-Server-and-ESB#webMethods