You need to install Integration Server 4.6 before installing Enterprise Web Manager because the latter depends on the former for HTTP requests.
Typically, you install IS4.6 into:
C:\webMethods\IntegrationServer4
You then need to specify this directory name, right after you log in the Universal Installer. This will place a bunch of code files under:
IntegrationServer4\packages\WmEnterpriseAdmin
You finally need to start IS4.6 before you can invoke EWM with:
http://localhost:5555/WmEnterpriseAdmin
TN
#webMethods#webMethods-General#Integration-Server-and-ESB