Yes. As long as full access to all features of the database is is available. And the database vendor and version are supported by the version of CPE in use, cloud-based offerings are supported. This is stated Software Product Compatibility Report (SPCR) for the product FileNet Content Manger on the prerequisites tab, database section:
"Unless otherwise noted, the listed databases are supported on any operating system or hardware environment that is supported by the database vendor. This includes appliance-based offerings and cloud-based offerings, as long as the device- or cloud-based database offering provides full access to all of the features of a database."
https://www.ibm.com/software/reports/compatibility/clarity/softwareReqsForProduct.html
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