We have a vendor that changed the connection URL we used to connect to them. I need to update the cache so we resolve to the new instead of the old is there a way to clear the old URL that is cached with out restarting Integration server so we resolve to the new hostname.

Thanks in advance

Are you talking about web service URL? If so, where do you think this URL is cached? Are you caching explicitly?

If you have already web service end point aliases created and assigned to that consumer (web service descriptor), you can point the new location in that alias which will reflect during invocation.

-Senthil