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Bonferroni correction with Mann-Whitney and Wilcoxon-signed rank

  • 1.  Bonferroni correction with Mann-Whitney and Wilcoxon-signed rank

    Posted Tue June 13, 2023 06:11 AM
    Edited by Asmaa Saeed Tue June 13, 2023 08:16 AM
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    Hello, my question maybe simple but I am a newbie so I apologize in advance

    I am analyzing the results of a clinical trial where I had 2 groups of patient who received a treatment or a placebo, group 1 = 22 patient and group 2= 21 patient.

    I had serum biomarkers analyzed at baseline and at 2 months and the data is non-parametric

    I compared the baseline of the 2 groups and the end result at 2 months for the 2 groups using Mann-Whitney + I compared the within-group result (before vs. after) for each group using Wilcoxon-signed rank test.

    what correction shall be done to account for multiple comparison?

    I think I need to multiply the P-values by 4 as a Bonferroni correction?? is that correct? If I do this then some P values end up being bigger than 1 and I have had a comment that it is unusual, so which is it?



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    Asmaa Saeed
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