Krishna,
If you want a 4-node cluster, then Case 1 is what you want. It will be resilient against failure of any one machine without human intervention. If you lose the entire non-prime site, then also no human intervention will be needed. Only if you lose the entire prime site, will it be necessary to manually set the prime flag on the other site to restore cluster operation.
Case 2 is not supported and will not work. You cannot set the prime flag on both sites.
I don’t understand Case 3, but if you mean having your UM sites not matching the actual data centers, then this will also be a non-supported configuration that will not work.
Check out this video for more details on UM clustering: [url]http://techcommunity.softwareag.com/pwiki/-/wiki/Main/Universal+Messaging+Clustering+Demystified[/url]
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