All TN Objects (profiles, doc types, processing rules etc) are cluster aware and since they use same same TN database so updating them at 1 node would reflect in other node too. BUT do we have to do some extra settings to make TPA cluster aware?
Seems that normally TPA is not cluster aware (even though using same database) and we need to change at both nodes if we want to change any value inside TPA.
We need to do some configuration to make TPA Cluster aware (changes at one node reflect at another) ??

Actually, TN objects have no notion of being in a cluster whatsoever.

There are TN properties that need to be set that cause one TN to notify the others that TN objects have changed so they need to reload their cache.

Refer to the docs and on-line help for TN notify config settings.