smtp service only sends a email, period.
As part of the text sent in the email, you can add a “Please do not reply” text, however you cannot control if a remote user decides to reply or not, or if has an Out Of the Office and automatically replies.
Why don’t you simply send a email with a dummy email account that if receives any email back it automatically deletes it?
#Flow-and-Java-services#Integration-Server-and-ESB#webMethods