Why do you want to change the location of DocumentStore? Any specific reasons?
Server restart is required for settings to take effect.
By default, the Integration Server saves document stores in the following directory:
IntegrationServer_directory\DocumentStore
If you want to save the default document store in a different location, specify the directory in this field. If the directory does not exist, the server creates it.
#webMethods#broker#Integration-Server-and-ESB#Universal-Messaging-Broker