Do you receive a real MDN (with header etc.)? or just that “conncetion: close”?
If it’s later case, your request is not reaching your client’s internal system, which should generate a proper MDN.
Check with your network team and client side for:
if any Proxy/Load balancer that’s blocking the connections on your side or client side.
That error doesn’t seem a WM system error, must be some other in-between system that is trying to connect to the destination system, and failed.
#B2B-Integration#webMethods#Integration-Server-and-ESB