Hi RMg,
Thanks for showing interest to my question, which leads to help me 
giving you a brief, in one geo location, I am recommending to have the IS in cluster, at the same time this location is load balanced with other geo location with the identical setup.
Looking at the continuous availability of the Integration Servers I am thinking, if we can bring all the IS in cluster across the geo location.
I am not sure though, whehter it is recommended by SAG to have IS in cluster across the geo location. So trying to get expert’s opinion.
This will definitly point questions to the shared disk storage for cache management in terms of the cluster and other resources.
Thanks & Regards,
Shrinivas
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